In the process of working on a NIST Scientific Foundation Review on DNA mixture interpretation over the past two years, our team has gathered and studied the scientific literature on the topic and carefully considered principles and best practices. Key principles will be reviewed and a brief history of DNA mixture interpretation approaches will be presented. Some thoughts on reliability and relevance will be discussed in the context of measurement and interpretation issues involving probabilistic genotyping approaches that are being used to examine complex, low-level DNA mixtures.

Presented by by Dr. John Butler, NIST Special Programs Office, and Dr. Hari Iyer, NIST Statistical Design, Analysis and Modeling Group.

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